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Action Binds to certain opioid receptors and inhibits reuptake of norepinephrine and serotonin; exact mechanism of action unknown. Indications Relief of moderate to moderately severe pain. Contraindications Acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids or psychotropic agents. Carbamazepine: May reduce serum tramadol Valium Sleeping Pills levels, leading to decreased effectiveness.
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